This drug has not been approved for medical use in the United States, Canada, the United Kingdom or Australia. It is sold under numerous brand names such as Noofen, Fenibut, and Anvifen. Phenibut is a Russian developed nootropic used quite extensively for clinical therapy in Eastern Europe. It acts as a GABA mimetic on the subclass of metabotropic transmembrane GABA-B receptors, which are also involved in mediating the effects of alcohol. Phenibut was derived from GABA and can mimic some of the effects of this neurotransmitter in the brain. These GABA agonists reduce neuron receptor “overexcitation” which can trigger anxiety, stress responses, and similar reactions in the body. The effect of GABA and GABA-like drugs is decreased neuronal activity. It is involved in the regulation of normal brain signaling and helps to ensure that only the most important messages between neurons gets passed on. GABA is chemical messenger in the brain whose primary function is to slow down or antagonize activation of neural circuits.

Phenibut ( beta-phenyl-gamma-aminobutyric acid HCl) is a nootropic agent that is similar in structure to the inhibitory neurotransmitter, gamma amino butyric acid (GABA). Taking dosages required to produce dissociation with reality or euphoria can result in toxic side effects and may be potentially lethal if using this substance in combination with other Central Nervous System depressants including alcohol, other Gabapentinoids and benzodiazepines. But these effects will only occur if the drug is abused at dosages several times greater than the standard amount used for therapeutic purposes. While some describe a sense of euphoria, sedation, and disinhibition, others describe depression, lethargy, anxiety, hallucinations, confusion and a number of additional unpleasant side effects linked to recreational use.Ĭan you get high off of Phenibut? Like other GABAergic drugs, this nootropic agent can cause an anxiolytic effect which may be described as a “mental high”. In these user reviews, you will find a huge variability in responses to high dosages of this nootropic drug. Search Google for the keywords “Phenibut high” and you will find countless experience logs posted by reviewers on online forums like, Reddit,, Longecity and Erowid. There appears to be considerable interest in the use of Phenibut to promote a “high” sensation online. It is typically taken off-label for mood enhancement, as a sleep aid and anxiolytic.īecause Phenibut affects similar receptors in the brain as alcohol, high dosages can impair cognition, motor control and neurological function and lead to dangerous negative effects. While Phenibut is a legal (uncontrolled) substance in the United States, it has not been approved for medical use.

It has been prescribed to both children and adults with a typical dosage of 250 mg per administration. Phenibut has been used to treat anxiety, post-traumatic stress disorder, motion sickness, dizziness and other conditions in Russia, Latvia, Georgie and the Ukraine. There have been dozens of serious adverse effects documented in case studies from people using high dosages of this substance. Online sources describe taking it with the intention of promoting a “ buzzed” or “ intoxicated” feeling.ĭoing so is inherently dangerous and poses a considerable risk of harmful side effects, including overdose, hospitalization, unconsciousness, mania, memory impairment, dystonia, seizures, and more. Can taking phenibut at high dosages produce euphoria and a drug-like experience? Is this Russian nootropic a legal high?Īdministration of high Phenibut dosages for recreational purposes is reported by users in nootropic forums like Reddit and Longecity.

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